Grey’s Anatomy: The Truth About Actors Katherine Heigl and TR Knight’s Relationship

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When Grey’s Anatomy aired in 2005, we were introduced to a cast loaded with great celebrities and major actors who gave the series great flight. Katherine Heigl and TR Knight, played best friends, George and Izzie. They were the first to leave the Seattle Grace Memorial, now known as the Gray-Sloan Memorial. In season 5, Knight’s character died after jumping in front of a bus to save a woman’s life and Izzie left the following season without a proper send-off.

Katherine Heigl’s departure gave fans the impression that she parted ways with the Grey’s Anatomy team. Then there was her “bitter” reaction to Alex’s reunion with Izzie, the season 16 plot twist that marked Justin Chambers’ departure from the show. In 2012, she told her that she was still in contact with her former co-stars, including Chambers and also revealed that Knight was her best friend in real life. But these days, they aren’t even followed on Instagram.

There was a lot of drama surrounding Heigl’s departure from Grey’s Anatomy and she was later labeled “difficult” to work with, a reputation that would haunt her career for years to come. Later in 2010, the actress revealed that it really was a vacation at her family’s home in Utah that “changed my whole perspective.” At the time, Heigl had just adopted a 9-month-old baby, her oldest son, 12-year-old Naleigh.

Fans also speculated that tension between Heigl and former co-star Isaiah Washington may have prompted the decision. At the 2007 Golden Globes, the Ugly Truth star publicly criticized the The 100 actor for using a gay slur. Could so much drama have affected the actress’s relationship with other members of the Grey’s Anatomy cast?

Katherine Heigl had expressed in several interviews that her best relationship in the series was TR Knight and from there multiple images of the actors sharing great moments were seen, including on her own social networks.

But fast forward to 2021, Katherine Heigl and TR Knight are not followed on Instagram and not much more has been heard from them as friends. Fans thought it was weird as she’s mutual with other actors she’s worked with, like Grey’s Anatomy lead star Ellen Pompeo and Josh Duhamel. Maybe they just took care of their own lives. Think about it, until Patrick Dempsey’s cameo in season 17, fans thought he and Ellen Pompeo were no longer friends and they had one of the most emotional reunions of all.