Coronavirus: Scientist plans to create neutralizing polymer

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The coronavirus has caused scientists and governments to run for immunizations around the world, however physicist Mónica Olvera says she has found a way to reduce the effectiveness of coronavirus infection in the human body through studies with her team at Northwestern University in the USA. Understand how this can even neutralize Sars-CoV-2 in the future.

Mónica says that the weak point of the virus was found by checking the differences between the coronavirus of the 2003 SARS epidemic and that of the current pandemic, responsible for COVID-19. The researcher says that the main difference is the attraction load between the S proteins of the virus and the enzymes of human cells, which was much smaller in the SARS epidemic.

Thus, a study with researcher Baofu Qiao analyzed the load of these S proteins present in the spikes (which look like thorns around the coronavirus) and realized that they can be blocked.

At this point, one of the three classes of proteins on the spikes was blocked in a test, which resulted in a 30% drop in the coronavirus’s effectiveness in connecting to human cells.

Before the virus enters (into the body’s cells), we can attack it so that it no longer has so much attraction energy, that it is not able to infect. And if you get in, let it be blocked there, “explained Olvera.
The idea now is to develop a polymer that attacks the three proteins of the virus’s spikes, eliminating the possibility of it infecting human cells.

“It is another form of cure. They are not antibodies, to which viruses can be resistant. There are many cases in which viruses become resistant to antibodies.”
The big challenge is to create a polymer that can be metabolized by the organism, in a way that does not cause any damage, since so far the tests have only been carried out in laboratories.

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The creation of this chemical compound can take between 2 or 3 months. Olvera believes that the best solution would be through an aerosol.

Another difficulty alerted by the researcher is that the virus can use mutations, use structures of other viruses and even RNA to overcome these “barriers” created by the polymer, however if he continued to use the same proteins, the method developed by the researcher would continue to be very effective .

Monica Olvera completes saying:

“We want to create something that is not biological, that does not create resistance. To prevent the virus from finding other ways to progress. We believe that it may be a way to weaken the virus, different from what is being done.”
For now, the great hope for fighting the coronavirus is vaccines, where the Chinese vaccine has already been approved for emergency use.


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